Enzyme Inhibitors Drugs Industry

Enzyme Inhibitors Market Analysis

The Enzyme Inhibitors Market is expected to register a CAGR of 3.95% during the forecast period.

• The COVID-19 pandemic had a significant impact on the enzyme inhibitors market. With the emergence of the infectious and virulent coronavirus in the past year, it became essential to understand the cause of the infection. Enzyme inhibitors have helped investigate the enzymes responsible for allowing viral entry and the potential for inhibition to reduce the severity or prevent COVID-19.
• For instance, a study published by Elsevier Public Health Emergency Collection in October 2021 identified enzymes responsible for SARS-CoV-2 viral entry into cells and compounds proposed to inhibit viral access to treat COVID-19 infection. Thus, the increasing number of COVID-19 cases led to a growing demand for enzyme inhibitors. However, due to the increased vaccination and availability of other drugs for COVID-19 treatment, the market has lost some traction gained during the pandemic. Nevertheless, the market is expected to have favorable growth due to the presence of other infections over the forecast period.
• The growth of the enzyme inhibitors market can also be attributed to the increasing demand for effective and accurate drugs, the exponential rise in diseases like cancer, and rising global agricultural activities and pharmaceutical establishments. For example, cancer is a complex multifactorial disease that results from alterations in many physiological and biochemical functions. Cancer cells can acquire multidrug resistance to conventional anticancer drugs, resulting in tumor relapse. Thus, there is a continuous need to discover new and effective anticancer drugs, which is expected to increase the demand for enzyme inhibitors and drive the market's growth. The rising trend of launches, acquisitions, and collaborations in the pharmaceutical industry also drives the market's growth.
• The Cancer Facts & Figures 2023 data published by the American Cancer Society shows an estimated 1.9 million new cancer cases diagnosed and 609,820 cancer deaths in the US in 2023. The exponential rise in the prevalence of diseases like cancer is expected to drive the market's growth. In April 2021, Artios Pharma Limited collaborated with Novartis International AG to uncover and verify new generation DDR targets to advance Novartis' Radioligand Therapies. Additionally, in March 2021, Amgen Inc acquired Rodeo Therapeutics Corporation, recognizing the potential value and differentiated profile of Rodeo's lead 15-prostaglandin dehydrogenase inhibitor program.
• However, the patent expirations of enzyme inhibitor drugs and the availability of low-cost generic drugs restrain the market growth. Overall, the enzyme inhibitors market is expected to grow over the forecast period, driven by the factors mentioned above.

Enzyme Inhibitors Market Trends

Kinase Inhibitors Segment Is Expected to Hold a Significant Share in the Enzyme Inhibitors Market

• Kinase inhibitors are a class of enzyme inhibitors that obstruct the activity of one or more protein kinase enzymes. Protein kinases are enzymes that add a phosphate group to a protein, altering its function. Certain types of kinases are more active in various cancer cells, and blocking these kinases may help impede cancer cell growth.
• The escalating prevalence of target diseases such as cancer and cardiovascular disease, as well as the increase in kinase inhibitors for treating these diseases, have been driving the growth of this segment. For instance, a study published by the British Heart Foundation in February 2023 indicated that around 7.6 million people in the United Kingdom were living with heart disease in 2021.
• Moreover, an article published by the National Library of Medicine (NLM) in November 2022 revealed that 72 Food and Drug Administration (FDA)-approved therapeutic agents target about two dozen protein kinases, with three of these drugs being approved in 2022. Of the approved drugs, twelve target protein-serine/threonine protein kinases, four are directed against dual specificity protein kinases (MEK1/2), sixteen block nonreceptor protein-tyrosine kinases, and 40 target receptor protein-tyrosine kinases. Sixty-two of these drugs are prescribed for the treatment of neoplasms.
• Four drugs (abrocitinib, baricitinib, tofacitinib, and upadacitinib) are used to treat inflammatory diseases (atopic dermatitis, psoriatic arthritis, rheumatoid arthritis, Crohn's disease, and ulcerative colitis). The increasing availability of kinase inhibitors for treating target diseases is expected to drive segmental growth.
• Furthermore, acquisitions, partnerships, mergers, and collaborations by key players in the market are expected to boost the segmental market. For example, in March 2021, Pfizer Inc. received United States Food and Drug Administration (US FDA) approval for a supplemental new drug application (sNDA) for LORBRENA (lorlatinib), a TKI, expanding the indication to include first-line treatment of people with anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC). LORBRENA is indicated for adults with metastatic NSCLC whose tumors are ALK-positive as detected by an FDA-approved test.
• Thus, all of the aforementioned factors, including the growing prevalence of target diseases such as cancer and cardiovascular disease, the increase in kinase inhibitors for treating these diseases, and the mergers and partnerships of key players, are expected to contribute to the growth of this segment over the forecast period.

North America Is Expected to Hold a Significant Share in the Enzyme Inhibitors Market

• The growth of North America's market is driven by several factors, including a well-established healthcare infrastructure and increased government initiatives that offer attractive reimbursement policies. Additionally, the rising incidence of cancer is a significant factor driving the enzyme inhibitors market's development.
• According to the American Cancer Society's 2023 update, more than 1.9 million new cancer cases are expected to be diagnosed in the United States this year, excluding basal and squamous cell skin cancers and carcinoma in situ, except for the urinary bladder. Similarly, the Canadian Cancer Statistics 2021 report released in November 2021 estimated that two out of five Canadians would be diagnosed with cancer in their lifetime, with 229,200 Canadians diagnosed in 2021. Consequently, the growing prevalence of cancer in North America is expected to have a substantial impact on the market's expansion.
• In addition, the introduction of innovative products using enzyme inhibitors to treat multiple conditions is expected to drive market growth. For example, in July 2021, Ocular Therapeutix Inc. initiated the first patient in the United States Phase 1 clinical trial of OTX-TKI (axitinib intravitreal implant) to treat wet age-related macular degeneration (wet AMD). Additionally, in June 2022, Pfizer Inc. submitted a New Drug Application (N.D.A.) to the USFDA for the approval of PAXLOVID (nirmatrelvir and ritonavir tablets) for high-risk patients who are likely to progress to severe illness from COVID-19. As a result, ongoing clinical trial processes in this market are expected to promote its growth.
• In summary, the factors mentioned above, including a developed healthcare infrastructure, increased government initiatives, and the growing incidence of cancer, are expected to contribute significantly to North America's strong growth in this market over the forecast period.

Enzyme Inhibitors Industry Overview

The market for enzyme inhibitors is moderately concentrated, with companies operating globally and regionally. The competitive landscape includes an analysis of a few international as well as local companies that hold significant market shares and are well-known, such as Abbott Laboratories, Amgen Inc., AstraZeneca PLC, Bayer AG, Boehringer Ingelheim International GmbH, Bristol-Myers Squibb, Cipla USA Inc., F. Hoffmann-La Roche, Novartis AG, Pfizer Inc., and others.

Enzyme Inhibitors Market Leaders

Enzyme Inhibitors Market News

• In January 2023, AstraZeneca announced its acquisition of CinCor Pharma, Inc. The acquisition aims to enhance AstraZeneca's cardiorenal pipeline by including CinCor's candidate drug, baxdrostat (CIN-107), an aldosterone synthase inhibitor (ASI) for reducing blood pressure in cases of treatment-resistant hypertension.
• In April 2022, Daewon Pharmaceutical launched Escorten, which is one of Korea's first proton-pump inhibitor drugs. Escorten contains esomeprazole magnesium trihydrate and is available in a 10 mg dosage.